Eh b-vitamins tend to get toxic at about 1000x RDA levels, but high folic acid supplementation has been associated with increased cancer risks, perhaps.
As far as the evidence that taking high levels of B vitamins for mental health, in my opinion there's conflicting data in small trials and mouse studies but in larger human trials with objective measurements there is no point to supplementing if you live in a country that fortifies its food, have no small intestine pathology (e.g. celiac or Crohn's), and aren't an alcoholic/malnourished.