No, as the modulation of the Hypothalamic-pituitary-gonadal axis via "gluten" in Celiac's appears to be secondary to the inflammatory cascade.
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Gluten and prolactin
Serum prolactin levels after administration of the alimentary opioid peptide gluten exorphin B4 in male rats. - PubMed - NCBI
I'm not a doctor but the administration was IV on male rats and they didn't show the increase but I guess it was statistically significant.
Is this something non celiac/gluten sensitive people should be concerned for optimal testosterone levels?
✓ Member
No, as the modulation of the Hypothalamic-pituitary-gonadal axis via "gluten" in Celiac's appears to be secondary to the inflammatory cascade.
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Are the peptides really absorbed in large enough quantities enough to have this effect?
Also, peptides shouldn't be passing the blood brain barrier, so do they not have this effect directly in the brain? I've always found this stuff confusing.
✓ Member
What peptides are you talking about?Originally Posted by hugsaredrugs
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It may be a long shot but maybe gluten peptides! Haha
✓ Member
There is no such thing as gluten peptides.
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Really? Oh well
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As the NON celiac gluten sensitivity condition is about as clear as mud, what question exactly are you asking? That eating gluten in the absence of celiac sprue causes hypogonadism or lowers testosterone levels? Gluten isn't some systemic "toxin". It causes an autoimmune disease whereby antibodies to gliadin essentially destroy the gut via a ramped up inflammatory response in patients with celiac disease. This happens in roughly 0.5-1% of the population. And patients with one autoimmune condition often are susceptible to others.
The presence of a true non celiac disease is up in the air, much less the proposed mechanism, the prevalence, how to diagnose, etc. There's certainly less, or nothing, to suggest that it would impact the hormonal axes. One of the importances of properly diagnosing true celiac is because these patients are at an increased risk of colon cancer, something that is very readily and easily detected and treated with proper monitoring, ie it saves lives. It's not just about avoiding wheat.
✓ Member
Yes. Gluten is a protein made up of constituent polypeptides, which in a celiac react with the cells lining the small intestine where they generate antibodies and trigger the immune cascade replete with cytokines. The protein and polypeptides themselves get broken down into amino acids and do not make it into the blood stream.
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Wait, the amino acids make it into the blood stream and the polypeptides don't?
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