Never heard of a negative effect from whey. There is some data out there suggesting that whey can improve serotonin function and cognitive performance in stress-vulnerable subjects, however (see here). Remember, serotonin is one of the neurotransmitters targeted by SSRI's and other pharmaceuticals used to treat mood disorders currently. I am not suggesting whey is as good as an anti-depressant or that it is an anti-depressant....though creatine on the other hand....