Cross-posted from another thread, because it seemed relevant to readers of this article:
None of this. If I didn't take aspirin and tylenol, I would take ibuprofen and tylenol. The reason I take aspirin is because I'm 53. I take a daily 81mg aspirin to reduce my risk of cardio-cerebrovascular events. As should
everybody over 45, unless they have a contraindication. Since I take aspirin daily anyway, and since
ibuprofen appears to mess up the protective effect of aspirin, when I have pain, I just take more aspirin. For the young folk, either aspirin or ibuprofen will do nicely.
I have found that aspirin + tylenol will bitch-slap just about any pain I have, short of a gunshot wound, broken bone, full-thickness burn or my semi-biannual severe back tweak. I try to avoid these situations, but as an International Man of Mystery I find this is not always possible.