CNS Fatigue

[JNussbaum]

I have a background in neuroscience (Neurodegeneration, not Ex Phys) and keep coming across the term "CNS fatigue" to describe a particular type of overtraining/burnout. However, I can't find a legitimate explanation of what is consists of physiologically. Do you have any idea what people actually mean by this? Are they really proposing that the brain as "tired" and that it simply can't elicit a motor response because we have worn it out? I can't think of any biologically plausible explanation for something like that happening and am wondering if this is a real phenomenon that I am not aware of, or if people are just making things up.

[Mark Rippetoe]

I think it's just an internet broscience term, used by people unfamiliar with neuromuscular physiology. I have yet to see a neural mechanism proposed to explain it. Neither has Stef, who has a terminal degree in neuroscience.

[Jonathon Sullivan]

Neuromuscular Fatigue (n.): a condition in which a variable and subjectively-determined level of training intensity and volume have depleted presynaptic and synaptic cleft concentrations of spunkamine. Spunkamine is a catechol neurotransmitter that mediates a number of critical higher brain functions, particularly determination, fortitude, resilience, commitment, perception of gonadal size, and self-respect. Spunkamine is found exclusively in the neocortex, in areas involved with attention, imagination, and self-loathing. Motor end-plate neurotransmitter concentrations, nerve conduction velocities, motor unit recruitment and high-energy phosphate levels and myophysiology are unaffected in this disorder. This tragic condition is the subject of intensive research, particularly by franchise fitness facilities, supplement manufacturers, and personal injury attorneys.

[melody]

Neuromuscular Fatigue (n.): a condition in which a variable and subjectively-determined level of training intensity and volume have depleted presynaptic and synaptic cleft concentrations of spunkamine. Spunkamine is a catechol neurotransmitter that mediates a number of critical higher brain functions, particularly determination, fortitude, resilience, commitment, perception of gonadal size, and self-respect. Spunkamine is found exclusively in the neocortex, in areas involved with attention, imagination, and self-loathing. Motor end-plate neurotransmitter concentrations, nerve conduction velocities, motor unit recruitment and high-energy phosphate levels and myophysiology are unaffected in this disorder. This tragic condition is the subject of intensive research, particularly by franchise fitness facilities, supplement manufacturers, and personal injury attorneys.

I spit out my coffee laughing.

[Michele Knaub]

Bravo, sir.

[Tom Campitelli]

Spunkamine. Damn, that is good.

[GrimmThing]

What is the biological mechanism that create overtraining?

[tallison]

Neuromuscular Fatigue (n.): a condition in which a variable and subjectively-determined level of training intensity and volume have depleted presynaptic and synaptic cleft concentrations of spunkamine. Spunkamine is a catechol neurotransmitter that mediates a number of critical higher brain functions, particularly determination, fortitude, resilience, commitment, perception of gonadal size, and self-respect. Spunkamine is found exclusively in the neocortex, in areas involved with attention, imagination, and self-loathing. Motor end-plate neurotransmitter concentrations, nerve conduction velocities, motor unit recruitment and high-energy phosphate levels and myophysiology are unaffected in this disorder. This tragic condition is the subject of intensive research, particularly by franchise fitness facilities, supplement manufacturers, and personal injury attorneys.

Aha! So, it *does* exist!

[tallison]

Neuromuscular Fatigue (n.): a condition in which a variable and subjectively-determined level of training intensity and volume have depleted presynaptic and synaptic cleft concentrations of spunkamine. Spunkamine is a catechol neurotransmitter that mediates a number of critical higher brain functions, particularly determination, fortitude, resilience, commitment, perception of gonadal size, and self-respect. Spunkamine is found exclusively in the neocortex, in areas involved with attention, imagination, and self-loathing. Motor end-plate neurotransmitter concentrations, nerve conduction velocities, motor unit recruitment and high-energy phosphate levels and myophysiology are unaffected in this disorder. This tragic condition is the subject of intensive research, particularly by franchise fitness facilities, supplement manufacturers, and personal injury attorneys.

...but never fear, it ain't nothing a jug of Restor (TM), my own just-now kitchen-brewed endogenous spunkamine reuptake inihibitor releasing factor won't set right (and, yes, we checked the logic of those qualifiers - it *will* cure you!). I'm still working out a stable formula, but we expect it to be available for a low, low price at your favorite neighborhood supplement distributor before your significant other can say, "gee, honey, didn't there used to be more spunk (in our relationship)?"!

[Wil F]

I think it's just an internet broscience term, used by people unfamiliar with neuromuscular physiology. I have yet to see a neural mechanism proposed to explain it. Neither has Stef, who has a terminal degree in neuroscience.

If you use an ill-advised grip during the bench and drop it on your neck, is that a terminal degree in broscience?