Acetaminophen works best on a headache, I use naproxen for musculoskeletal pain, and for an acute emergency I have some injectable ketorolac in inventory. To illustrate the ineffectiveness of opiate analgesics on me, I once had 3 dilaudid and a large iced-tea glass of delicious dry red wine -- what I am told is a fatal dose -- and not only did my destroyed knee not stop hurting even a little bit, I didn't get sleepy. Just laid there and read my book.