So as I noted, the primary distinction between the "mental" and "physical" adaptation mechanisms is the stress that is applied. Most notably is the apparent absence of a hormonal response of some kind; we know that as part of Selye's stage 1 there is a release of cortisol, epinephrine, and norepinephrine, and it is the high levels of these hormones that must be allowed to decrease back to some tolerable level (not necessarily zero or pre-stress baseline) and managed in order to facilitate continued adaptation. We want Stage 2 and not Stage 3.
Perhaps the "stress" applied in the mental adaptation model could be one that is artificial, such as is seen in performance anxiety. I wonder if a student could be mentally stressed enough by setting higher and higher expectations of grades, performance, and mastery of material that the stress response we so often see in physical training would provide some physiological benefit to accumulation of knowledge.
A possible example of application is on the job learning. I can say from experience as an engineer that it is an entirely different thing to solve a problem in a book than it is to solve a problem in a chemical plant. Expectations are much higher, and the results you provide can mean anything from a huge profit loss to a possible safety accident. I can also say with confidence that I learned way more on the job than I ever did in school; that being said, without what I learned in school, I would not be nearly as well equipped to do what I do on the job. Or is this merely the difference between audio, visual, and kinesthetic learning? Perhaps there is a connection there?
At the very least, the ability to apply knowledge under pressure may be enhanced, though retention of knowledge may not be affected. At the end of the day though, isn't this what matters from a practical standpoint?