Originally Posted by
John P
The important part of the discussion is the hypothesis that taking the vaccine, because it very narrowly targets the S-protein, will blunt the individuals ability to mount an innate immune response to the viral variants being selected for thanks to the vaccine.
There are 2 components to immunity:innate and acquired. Innate immunity exists without exposure to a pathogen and is non-specific. It is very robust in youth and declines in the aged and infirm. Acquired immunity is post-exposure kind of immunity and happens in response to vaccines (and pathogen exposure) and is very specific. When you take the vaccine, which targets the wild-type (non-variant) SARS CoV2, a very specific to the wild-type virus immune response happens. But the immune response is so specific, the immune response doesn't stop the SARS CoV2 variants but may interfere with the individual's innate immune response - thereby making those vaccinated MORE vulnerable to the variant viruses which are inevitably coming. This is the explanation for the largely unaffected young, the more severely affected elderly, the rapid appearance of variants, the failure at previous attempt to create vaccines for the SARS CoV1 due to antibody dependent enhancement (ADE).