COVID19 Factors We Should Consider/Current Events COVID19 Factors We Should Consider/Current Events - Page 1555

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  1. #15541
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    Quote Originally Posted by Mark Rippetoe View Post
    Somebody look up the Lethal Dose of ivermectin for a normal human, and the number of deaths it has caused over the past 30 years. I'm busy or I'd do it for you.
    FAQs - British Ivermectin Recommendation Development group
    Is ivermectin safe?
    Ivermectin is one of the safest medications known to man. It is safer than aspirin.
    It has been taken over 7 billion times in over 30 countries.
    Its inventors won a Nobel Prize for its efficacy and safety in 2015.
    There have been many studies confirming its safety. Merck Pharmaceuticals (the then patent holders) published a study confirming it safe at 10 times the recommended dose.
    An in-depth safety report based on the assessment of over 500 peer-reviewed articles on reported adverse events temporally associated with ivermectin treatment shows that the adverse effects of ivermectin used to be infrequent (< 2-5% of treated patients) and mild to moderate. They mainly consisted of dizziness, tremor, tingling and sleepiness; fever, fatigue and headache; nausea, abdominal pain and diarrhea; transient tachycardia and orthostatic hypotension; pruritus and rash. More severe neurological complications (e.g., seizures, confusion, encephalopathy) are possible, but rare. That ivermectin is routinely used throughout the world to treat scabies in elderly people without major safety issues is noteworthy.

    Several national pharmacovigilance networks and international organizations released information or opinions ascertaining ivermectin safety in human subjects treated with parasitic diseases. Likewise, no severe adverse reactions have seemingly so far been described in relation to off-label studies or clinical trials of ivermectin as a potentialprophylactic or curative treatment of COVID-19.
    Ivermectin (PIM 292)
    7.2 Toxicity
    7.2.1 Human data
    7.2.1.1 Adults
    Amounts approaching the therapeutic doses in
    animals (100 to 200 g/kg bodyweight) are not
    hazardous to humans. Ingestions of large
    quantities (10 to 100 times the animal
    therapeutic dosage) may produce symptoms
    resembling those observed in animal toxicology
    studies at high toxic levels.

    An adult female accidentally self-injected a
    small quantity (approximately 200 g/kg)
    subcutaneously. Twelve hours later she
    experienced colicky pain with nausea but
    recovered within 12 hours (MSD, 1988).

    Clinical studies of oral ivermectin given in
    doses from 2 to 200 g/kg (maximum 12 mg) have
    shown a pattern of adverse experiences that
    included only one serious event (transient
    stupor). The remaining adverse experiences were
    considered not serious and were chiefly of the
    type expected based on the characteristics of
    the underlying disease and the responses seen
    after treatment with other microfilaricidal
    drugs, except for reports of "depression" (not
    psychiatrically tested) in four patients in open
    studies (MSD, 1988).
    7.2.1.2 Children
    A 16-month-old boy weighing 15 kg ingested
    approximately 100 to 130 mg of ivermectin (as an
    injectable solution). Ten hours post-ingestion
    he had mydriasis in one pupil, with frequent
    vomiting, pallor, 35C temperature, tachycardia,
    somnolence and variable blood pressure. He
    developed urticaria the following day, and had
    recovered after three days (MSD, 1988).

    7.2.2 Relevant animal data

    Acute toxicity studies - LD50 (mg/kg) (MSD, 1988):

    Oral

    Mouse: Female 24.6 - 41.6; Male 11.6

    Rat (Infant): Male & Female 2.3

    Rat (Young Adult): Female 44.3 - 52.8; Male 42.8 -
    52.8

    Dermal

    Rat: 660

    At relatively high doses in animal toxicity studies, CNS
    effects and visual disturbances have been observed.
    Higher doses cause death due to respiratory depression.

    Ivermectin, given to rats IV at a dose of 4 mg/kg,
    produced moderate incoordination; 6 mg/kg induced a
    state resembling anaesthesia which began one minute
    after injection and lasted for four to five hours.
    Higher doses caused death due to respiratory depression
    (Hayes & Laws, 1991).

    In a 14-week oral toxicity study in dogs, no treatment-
    related effects were observed in animals given 0.5
    mg/kg/day. Dogs given 1 and 2 mg/kg/day development
    mydriasis and lost a small amount of weight. Four of
    eight dogs given 2 mg/kg/day developed tremors, ataxia,
    anorexia and became dehydrated (MSD, 1988).

    Dogs given oral doses of ivermectin at 10 mg/kg produced
    ataxia with tremor; at 40 mg/kg, death occurred due to
    respiratory depression (Campbell & Benz, 1984).

    Collie dogs have been shown to be more sensitive than
    other dogs to the toxic effects of ivermectin.
    Depression, tremors, mydriasis, ataxia, coma and death
    have been seen in Collie dogs at 100 g/kg orally and
    greater, but not at the recommended dose of the
    commercial product (6 g/kg) (Campbell & Benz, 1984).

    9.2 Chronic poisoning
    9.2.1 Ingestion
    Clinical experience of 50,000 patients who received a
    dose of 150 g/kg in community-based trials undertaken
    in Africa and Central America demonstrate an incidence
    of 9% reporting adverse effects. The large majority of
    these were of the Mazzotti-type (oedema, pruritis and
    rash), and dizziness, lymphadenitis, transient
    hypotension, arthralgia, myalgia, headache, and ocular
    irritation resulting from the sudden death of massive
    numbers of microfilariae, but in only 0.25% of patients
    were these rated as severe (WHO, 1990a).
    (so basically it wasn't the ivermectin, but the dead parasites in the body after ivermectin killed them that caused the side effects)

    12.2 Specific preventive measures
    Store in a cool place out of direct sunlight. Keep out of
    reach of children.

    Ivermectin is contraindicated in patients who have a history
    of immediate hypersensitivity to the drug.

    Rapid in-vivo killing of large numbers of microfilariae may
    induce a systemic or ocular response. This reaction may
    include optic neuritis, choreoretinitis, proteinuria,
    pruritus, rash and oedema.

    Ivermectin should not be administered to pregnant or
    lactating women, or to young children, unless it is
    considered that the benefits of therapy outweigh the

    potential risks from the drug. At therapeutic doses,
    clinical evidence to date indicates no increase in
    congenital abnormalities in humans. However, in animal
    studies at high maternotoxic doses foetal abnormalities have
    occurred. ivermectin is excreted in breast milk.

    Preliminary in vivo studies demonstrate that ivermectin can
    enhance some of the pharmacological actions of diazepam.


    Comparative evaluation of acute toxicity of ivermectin by two methods after single subcutaneous administration in rats - PubMed
    Similarly the LD(50) of around 50mg/kg indicated a wide margin of safety (250x) considering therapeutic dose of ivermectin as 200microg/kg.
    To keep an eye out for
    https://www.nejm.org/doi/full/10.1056/NEJMc1917344
    In some breeds of dogs such as collies, which are homozygotes for a nonsense mutation in ABCB1, and in Abcb1-knockout mice, ivermectin induces neurologic disorders that can be fatal.2,3 Few cases of neurologic disorders after ivermectin treatment have been reported in humans, and data are lacking on such a deleterious mutation in the human gene ABCB1.4

    We report the case of a 13-year-old boy admitted to the pediatric intensive care unit for impaired consciousness. He had received a single oral dose of ivermectin (0.23 mg per kilogram of body weight) to prevent scabies infection 2 hours 30 minutes before the onset of impaired consciousness. His condition worsened 6 hours after he received ivermectin, with persistent neurologic signs, including coma, ataxia, pyramidal signs, and binocular diplopia, as well as abdominal pain and vomiting. He was monitored for 48 hours; during this period, he had a fluctuating Glasgow score and normal results on paraclinical tests. He fully recovered after 48 hours (see the Supplementary Data 1 section in the Supplementary Appendix, available with the full text of this letter at NEJM.org).
    Whats really interesting though is VigiAccess
    VigiAccess was launched by the World Health Organization (WHO) in 2015 to provide public access to information in VigiBase, the WHO global database of reported potential side effects of medicinal products. Side effects – known technically as adverse drug reactions (ADRs) and adverse events following immunization (AEFIs) – are reported by national pharmacovigilance centres or national drug regulatory authorities that are members of the WHO Programme for International Drug Monitoring (PIDM). WHO PIDM was created in 1968 to ensure the safer and more effective use of medicinal products.

    VigiAccess do a search for:
    -Ivermectin you will find Total number of records retrieved: 5657 adverse events since 1992
    -hydroxychloroquine Total number of records retrieved: 32329 adverse events since 1968
    -COVID-19 vaccines Total number of records retrieved: 1886009 mainly since 2021 but interestingly they have its use listed since 2014
    of listed in the Reproductive system and breast disorders category for the covid vaccines, the number is 59442

  2. #15542
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  3. #15543
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    Quote Originally Posted by Brian Harlin View Post
    Indeed. Perhaps the medical community should do some reflection on that.

    As for the Media; if these local news agencies wanted to actually provide some public service and prevent overdoses of veterinary grade Ivermectin, they could provide the equivalent dose information to prescription ivermectin. They could easily do so while stating that they dont recommend or condone taking veterinary Ivermectin.

    ... if they actually wanted to provide a public service.
    Because it is obviously impossible take an overdose of a prescription medication.

    Quote Originally Posted by Dandd75 View Post
    Thank you.

    11 Toxicological information
    Acute toxicity:
    LD/LC50 values that are relevant for classification:
    70288-86-7 Ivermectin Comp. B1a
    Comp. B1b
    Oral LD Oral >15 mg/kg (adult human)
    LD50 ~80 mg/kg (dog)
    25 mg/kg (mouse)
    50 mg/kg (rat)
    >24 mg/kg (Rhesus monkey)
    Dermal LD50 406 mg/kg (rabbit)
    >660 mg/kg (rat)
    Inhalation LC50/4h >0.4 mg/kg (rat)
    LD Subcutaneous >1.6 mg/kg (adult human)
    LD50 55 mg/kg (rat)
    LD50 Subcutaneous ~10 mg/kg (juvenile dog)
    Primary irritant effect:
    on the skin: No irritating effect known.
    on the eye: No irritating effect known.
    Sensitization: No sensitizing effects known.
    Additional toxicological information:
    The product is not subject to classification according to internally approved calculation methods for
    preparations.
    When used and handled according to specifications, the product does not have any harmful effects according to
    our experience and the information provided to us.

    15 Regulations
    SARA
    Section 355 (extremely hazardous substances):
    None of the ingredients are listed.
    Section 313 (Specific toxic chemical listings):
    None of the ingredients are listed.
    TSCA (Toxic Substances Control Act):
    57-55-6 Propylene Glycol
    CA Proposition 65
    Chemicals known to cause cancer:
    None of the ingredients are listed.
    Chemicals known to cause reproductive toxicity for females:
    None of the ingredients is listed.
    Chemicals known to cause reproductive toxicity for males:
    None of the ingredients is listed.
    Chemicals known to cause developmental toxicity:
    None of the ingredients is listed.
    Carcinogenesis potential categories
    EPA (Environmental Protection Agency)
    None of the ingredients is listed.
    IARC (International Agency for Research on Cancer)
    None of the ingredients is listed.
    NTP (National Toxicology Program)
    None of the ingredients is listed.
    TLV (Threshold Limit Value established by ACGIH)
    None of the ingredients is listed.
    MAK (German Maximum Workplace Concentration)
    None of the ingredients is listed.
    NIOSH-Ca (National Institute for Occupational Safety and Health)
    None of the ingredients is listed.
    OSHA-Ca (Occupational Safety & Health Administration)
    None of the ingredients is listed.
    Now we just need the death count.

  4. #15544
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    Page 28: "Between 8 December 2020 and 11 June 2021, a total of 5,522 people died within 28 days of receiving a COVID-19 vaccine in Scotland"
    https://beta.publichealthscotland.sc...ion_report.pdf

    Population is 5.4M

    10,500 total deaths since the beginning of the pandemic, where Covid was mentioned on the death certificate:
    Deaths involving coronavirus (COVID-19) in Scotland | National Records of Scotland

    __________________________________________________ __

    And this is very sad for dozens of reasons: COVID: Titusville teen in ICU, fighting pneumonia in both lungs

  5. #15545
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    Our Incompetent Woke Military: Three Star General Posts Photo She Thinks Are U.S. Troops Leaving Afghanistan–Turns Out They’re British

    Our Incompetent Woke Military: Three Star General Posts Photo She Thinks Are U.S. Troops Leaving Afghanistan--Turns Out They're British

  6. #15546
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    Quote Originally Posted by anticausal View Post
    You want a reason and a who for the plandemic, Mr. Barry Charles? This guy is very, very warm. And here's an archive, just in case something happens to it.
    The article asserts its easy to connect the dots. Here is my interpolation , but I did not find it easy.

    The giant financial entities used the pandemic as a clever way to preserve capitalism, which was heading to the bottom. ( not clear how much was self preservation and how much was altruistic)

    Does that cover the who and why?

  7. #15547
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    https://mobile.twitter.com/Partisang...604792320?s=09

    The french are the most reactive.
    Italy is pretty much in the shitter. We are so compliant that nobody is even enforcing anything. We've had planned protests against the passport vaccine every saturday evening for the past few weeks, only a couple cities with large attendances, nothing crazy going on, just people shouting liberty to the wind.
    When we're gonna have the passport for shopping malls nothing will happen, I'm pretty sure.
    Our prime minister, Draghi, actually talked about mandatory vaccination, and third doses of course.
    Some other guy said that if kids in a classroom are fully vaccinated they can take their masks off. Imagine the kind of discrimination this creates when only one kid is not vaccinated and everyone has to keep a mask on because of him.
    Parents even had the nerve to complain about this, the opposite way, demanding mandatory masking even when everyone is vaccinated. They are nothing but child abusers.

  8. #15548
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    Quote Originally Posted by anticausal View Post
    You want a reason and a who for the plandemic, Mr. Barry Charles? This guy is very, very warm. And here's an archive, just in case something happens to it.
    The start of the article is not bad, but it quickly descends into the Marxist historical necessity idiocy. Pro tip, Italian Marxists in particular have been announcing the end of capitalism due to the impoverishment of workers for 80 years now. My guess is this results from living in a permanently bankrupt state which should really be super rich based on how much it is producing. It is a specifically strange phenomenon. Though I find it funny that conservatives and leftists are on the same page vis-a-vis the Davos trolling thing.

  9. #15549
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    DAN ANDREWS'&#39;' PRISON HOTEL '&#39;'QUARANTINE'&#39;' IS DRIVING PEOPLE INSANE
    #QUARANTINE Wake-Up-Call

    A man stuck in a Melbourne 'quarantine' hotel captures the ruckus between a neighbouring prisoner and guards/police. It seems the man was scheduled for release but was then told he would have to stay longer, causing him to have a mental breakdown. A voice can be heard telling the man "calm down or you gonna get f**king gassed!"
    The man filming also describes what it's like enduring temporary hotel imprisonment under the guise of 'quarantine':
    "I feel for this guy, this is sh*t, this is hotel quarantine ... People go crazy in hotel quarantine, I relate to it big time.
    I'm supposed to be released at 11.59pm on Tuesday night ... I'm scared that after spending 14 days here, 338 hours, in one room with no air, and then they tell you you can't leave, I reckon I would go off as well.
    People can't understand the insanity of police hotel quarantine when you can't get any f**king air in here at all. It's madness, it's absolute madness."

  10. #15550
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    starting strength coach development program
    Quote Originally Posted by Mark Rippetoe View Post
    Page 28: "Between 8 December 2020 and 11 June 2021, a total of 5,522 people died within 28 days of receiving a COVID-19 vaccine in Scotland"
    https://beta.publichealthscotland.sc...ion_report.pdf

    Population is 5.4M

    10,500 total deaths since the beginning of the pandemic, where Covid was mentioned on the death certificate:
    Deaths involving coronavirus (COVID-19) in Scotland | National Records of Scotland

    __________________________________________________ __

    And this is very sad for dozens of reasons: COVID: Titusville teen in ICU, fighting pneumonia in both lungs

    “The analysis includes all recorded deaths due to any cause and does not refer to deaths caused by the vaccine itself. As the vaccination programme is being rolled out to the entire adult population, many people will experience an illness or death in the days following their vaccination by coincidence. This is particularly the case for those vaccinated early in the programme, when the programme prioritised the very elderly population and those with pre-existing underlying health conditions.”

    I’m not an advocate of mass vaccination having refused it myself, but cherry picking the data and presenting it like some tabloid fear headline isn’t helpful.

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