Ivermectin inhibits the entire life cycle of SARS-CoV-2 in our cells, including attachment, spreading, and replication (1, 2, 3).
Moreover, ivermectin is anti-inflammatory and organ-protective, which can potentially protect against severe COVID-related lung damage and acute respiratory distress syndrome, heart-related complications, and blood clots.
Ivermectin exceeds the approved antiviral effects of other medications, including Paxlovid, molnupiravir, and remdesivir, which target only the virus and lack anti-inflammatory and organ-protective effects. Monoclonal antibodies have to be constructed specific to each variant and are very expensive.
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Many doctors have observed the positive effects of ivermectin on their patients. An observational study conducted in Brazil with more than 88,000 patients showed that ivermectin reduced the rates of infection, mortality, and hospitalization by 49 percent, 92 percent, and 100 percent, respectively.
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The recommended dosage of ivermectin for treating COVID-19 is based on the clinical experiences of physicians worldwide.
The Front Line COVID-19 Critical Care Alliance (FLCCC) guidelines recommend taking 0.4 mg/kg of ivermectin daily, immediately after exposure. Once a cumulative dose in excess of 200 mg is reached, the risk of acquiring COVID-19 has been shown to be nearly zero.
It is common for a drug with multiple indications to have different doses for different diseases.
Moreover, ivermectin should be given with food, as it has a 2.6-fold higher bioavailability when taken with food than when taken on an empty stomach. The Merck package insert (revised May 2022) also supports this and states, “Administration of 30 mg ivermectin following a high-fat meal resulted in an approximate 2.5-fold increase in bioavailability relative to administration of 30 mg ivermectin in the fasted state.”
Yet this important dosing information is not reflected in the commonly used drug prescribing resource known as the Prescribers’ Digital Reference, which states: “Take the number of tablets your doctor has prescribed all at the same time with water on an empty stomach. Do not eat any food within two hours before or after taking the tablets.”
So if a person takes the dose while fasting, they are getting only 40 percent of the recommended dose. For patients with a higher body weight, the effects of underdosing could be even more significant.
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Furthermore, the analysis showed that ivermectin effectively reduced COVID-19-related hospitalizations and deaths. Only 1.6 percent of 2,157 patients in the ivermectin group experienced hospitalizations or deaths, compared with 4.4 percent of 3,256 patients in the usual care group.
Even a low dose of ivermectin has demonstrated the potential to save lives. However, the authors concluded, “Ivermectin for COVID-19 is unlikely to provide clinically meaningful improvement in recovery, hospital admissions, or longer-term outcomes.”
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In a randomized, double-blind, placebo-controlled clinical trial with mild to moderate COVID-19 patients, none of the 55 patients in the ivermectin group died, whereas four of 57 in the placebo group died. Moreover, only 1.8 percent of ivermectin-treated patients needed invasive ventilation compared with 8.8 percent in the placebo group.
In other words, ivermectin reduced the risk of death by 100 percent and the need for ventilators by 80 percent.