Originally Posted by
dfclark68
Umm. No. "CNS fatigue" is not an actual phenomenon--at least not a clinical phenomenon observed in living humans. Maybe you can find this term in a third-tier medical journal to describe a general effect in vitro. In the real world there are specific terms for specific states where specific neuron populations or parts of the CNS are metabolically stressed, such as ischemic stroke, toxic or metabolic encephalopathy, or epileptic seizures. Each of these clinical phenomena suggest specific pathology or insult to the homeostasis of the CNS.
Physical exertion or overexertion in a healthy human does not and cannot produce "CNS fatigue" unless you define it as a psychosomatic phenomenon.