Originally Posted by
Jason Donaldson
In. my experience, chronic, low-level pain can fly under my conscious radar remarkably well, and still have an impact on me. Analgesics have helped me with the second-order effects like stress, irritability, and yes, sleep quality when I'm not even constantly walking around thinking "I'm in pain now." When I treat the pain, I THEN notice the difference, and realize I was walking around irritated. It's not unlike what I've come to understand about walking around hungry - I don't need to be consciously aware of the hunger to be more of an asshole because of it.
As to mechanism, I've had it explained to me that NSAIDs (like Vitamin I) hit the source of pain, while acetaminophen hits your CNS's registering of it, and this is why they work together so well. I'm also told that this approach has shown great promise over opiates for managing chronic pain, quite possibly because of that effect.