Originally Posted by
Maybach
It is almost certainly a hormonal byproduct of training: the repair and growth processes that go on during sleep when recovering from sufficient stress to produce an adaptive response can cause sundry abnormalities. Cortisol and growth hormone in particular. Moving the training further from sleep will allow clearance of the cortisol from the training, but your body utilizes cortisol as part of the regulation of the inflammation produced during (or utilized by? The endocrine system is a riddle but you see what I am driving at) the actual repair and growth processes. I know that sometimes after an especially difficult training week, my wife says I'm a furnace throughout the night. Growth hormone and cortisol cause a spike in glucose from the liver, as well as insulin resistance, which can cause a high or low which can both cause you to wake up. This gets thornier when paired with the natural circadian cycle of cortisol. This is probably why you're waking up at 3 am: this is around when the "dawn effect" kicks in and begins increasing cortisol for your eventual awakening. If you are operating at higher levels, and the hormonal axis involved in muscle repair is going at full tilt, this can produce a premature awakening.
The NSAIDs before bed help to regulate this somewhat. Ibuprofen works until Vioxx gets back on the market.
The chief thing I've adjusted when facing a similar issue is nutrition. Protein and fat regulate both inflammatory response, repair processes, and blood glucose. The bodybuilder casein/peanut butter shake works well for this. So does a glass of warm milk. It can help "smooth" the insulin secretion over the night so you don't get changes, but by the same token also disturb that balance. Try consuming fats and proteins close to bedtime if you aren't already. If you are, try stopping. See if that changes anything.
You can also try examining your fat and carbohydrate intake. If you are consuming insufficient carbohydrates, you will face an excess of cortisol and the aforementioned blood glucose fluctuations will be exacerbated. If you are consuming an excess of fats, this can have a pro-inflammatory/hyperalgesic effect. And the inverse situation can produce corresponding imbalances. Try tweaking that by degrees and see if that helps