Michael Grantham
✓ Member

Fair enough. It's your world Coach. I'm easy to find if someone wants to have a real conversation.

I do. You asked what my motivations for posting here were, and this is part of it. Conversations like this one are important, and it's important to...

Ok. Now I understand what you're getting at. I think it was the correct guidance given what was known at the time. Protection from infection was much...

You don't like that wording. That's fine we can try another. How about 'the fraction of the population who are at risk for developing severe disease...

I disagree that neutralizing antibodies are the most important to public health. What is most important to public health is that if you get...

Neutralization by antibodies is one part of protection, but it is not the only thing. There is also opsonization, activation of the complement...

John and IPB. I appreciate the responses. Some good points in there to be sure. The vaccines are directed against more than just the receptor...

As far as tha vaccines go it IS fair to say that I am more pessimistic now than I was then. I didn't predict this rate of mutation. Coronaviruses...

I've worked in science labs since I was an undergraduate student...20-plus years. I've worked on projects funded by NSF, CDC, IARPA, private...

My point was that just because they don't provide protection against infection with the currently circulating variants does not mean that they are...

I'm aware that you do not believe the data largely because you do not trust the people providing the data. I get it that you don't think that people...

False. I don't have issue with other treatments. However none are as effective against severe disease in as many circumstances as vaccines are. ...

They're pretty good about explaining their sources. With some looking you should be able to find it pretty easily. Or we could just skip the...

I don't know exact numbers, but almost all of the cases in the US in 2022 have been due to the Omicron lineage and there have been close to 200,000...

Lots of stuff in the literature on this. Here is an example: Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies | Nature ...

I have, but my anecdotes aren't any more useful than yours. United States: COVID-19 weekly death rate by vaccination status - Our World in Data

What do you mean by non-correlative? What sort of study design would that be? This is largely due to mutation of B cell epitopes that allow...

Finally some common ground.

Do you really not see any value in a vaccine that reduces disease severity even if it does not prevent all infections? You picked an interesting...

It is just you. Only a few viruses require work at BSL3 or 4.

Has someone shown that shedding does occur?..iow has it been measured or is it speculated to occur?

BS. I've been here since 2010. I'm very well aware of the caliber of people who post on and read these forums. If it makes you feel better to think...

Agreed. The wording is not great. They state it more strongly further down. Which wording represents the actual situation...I cannot say. I don't...

There does not appear to be a correlation. So far most of the identified cases are in th UK, and as of about a week ago none of the UK cases had been...