..there are only 3 published case reports arising from the hundreds of millions of exposures to products containing sucralose during more than 15 years these products have been available. In addition, in each of these single patient observations, there are potential confounders of taste or ingestion of other food products, which should give pause to any researcher or clinician trying to draw conclu- sions from such data.
There are abundant data demonstrating the safety of sucralose. In assessing the overall safety profile of sucralose, one cannot ignore the extensive data showing that sucralose is well tolerated and safe for use in amounts hundreds of times greater than maximum estimated intakes. Clinical studies similarly show that sucralose is as well tol- erated as placebo.