Thanks for sharing. The thing is that the clinical implications of the in vitro lab work or plausible physiological mechanisms are not always tightly correlated. I find this occurs so often in my own self education when thinking about an issue, digging into the literature, then coming back full circle to human trials that show no difference, on balance. Good food for thought, certainly. Will have to keep digging and exploring, but I would caution those who may have hypothyroid or other related pathologies from putting too much stock in stuff like this without evidence showing clear clinical benefit without significant risks.
Needed, yes- but does supplementation help in hypothyroid folks? Doesn't appear so unless they are deficient, have a particular etiology causing low peripheral conversion, etc.
Surely by now you're well aware of the the placebo effect...not saying that's what is going on entirely, but it's not outside the realm of possibilities.Anyway, I swear every time I take a 200mg selenomethionine it feels like a caffeine pill in terms of wakefulness. I'd rather have prescription T3 from a doctor though instead of buying a supplement. Looks like I'll be seeing the endo in November-December, that sucks but I've survived till now.
None besides MAYBE vitamin D3. I don't think supplemental vitamin D3 has a clear benefit in most folks, but rather low levels are a marker of other things going on. Still, it's not clear enough for me to recommend against it entirely and there's some decent data supporting a modest dose for those who are deficient, elderly, or who live in northern latitudes without additional risk factors (renal stones). K2 supplementation is WAY less clear and mag and zinc almost certainly do not need to be supplemented in an apparently healthy adult who is eating ad libitum.Off-topic question for Jordan: what are truly common nutrients that one should really supplement with in a 1st world country? I am sure you'd agree that "deficiencies" are severely overblown by the alternative community and health blogs. Examine also says the same thing but say that Vitamin D3, magnesium and K2 are what most are missing. Do you think zinc should fall in that list too?